منابع مشابه
β Subunits of Voltage-Gated Calcium Channels
Calcium channel β subunits have marked effects on the trafficking and on several of the biophysical properties of all high voltage activated calcium channels. In this article I shall review information on the different genes, on the structure of the β subunits, and on their differential expression and post-translational modification. Their role in trafficking and assembly of the calcium channel...
متن کاملNa+ Channel β Subunits: Overachievers of the Ion Channel Family
Voltage-gated Na(+) channels (VGSCs) in mammals contain a pore-forming α subunit and one or more β subunits. There are five mammalian β subunits in total: β1, β1B, β2, β3, and β4, encoded by four genes: SCN1B-SCN4B. With the exception of the SCN1B splice variant, β1B, the β subunits are type I topology transmembrane proteins. In contrast, β1B lacks a transmembrane domain and is a secreted prote...
متن کاملReciprocal Interactions Regulate Targeting of Calcium Channel Β Subunits and Membrane Expression of Α1 Subunits in Cultured Hippocampal Neurons*
1 RECIPROCAL INTERACTIONS REGULATE TARGETING OF CALCIUM CHANNEL β SUBUNITS AND MEMBRANE EXPRESSION OF α1 SUBUNITS IN CULTURED HIPPOCAMPAL NEURONS* Gerald J. Obermair, Bettina Schlick, Valentina Di Biase, Prakash Subramanyam, Mathias Gebhart, Sabine Baumgartner and Bernhard E. Flucher From Department of Physiology and Medical Physics, Innsbruck Medical University, and Department of Pharmacology ...
متن کاملCalcium Channel Function Regulated by the SH3-GK Module in β Subunits
sion of the ␣ 1 subunit alone produces a voltage-depen-2 Department of Pharmacology dent calcium current, but these " ␣ 1 only " channels ex-3 Division of Cardiology press poorly and display abnormal kinetics of channel Department of Medicine activation and inactivation as compared to endogenous sion of an ␣ 1 subunit with an ␣ 2 ␦ subunit and a  subunit 4 Institute of Molecular Biology and im...
متن کاملβ Subunits Functionally Differentiate Human Kv4.3 Potassium Channel Splice Variants
The human ventricular cardiomyocyte transient outward K+ current (Ito) mediates the initial phase of myocyte repolarization and its disruption is implicated in Brugada Syndrome and heart failure (HF). Human cardiac Ito is generated primarily by two Kv4.3 splice variants (Kv4.3L and Kv4.3S, diverging only by a C-terminal, S6-proximal, 19-residue stretch unique to Kv4.3L), which are differentiall...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2001
ISSN: 0021-9258
DOI: 10.1074/jbc.c100273200